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. Author manuscript; available in PMC: 2020 Dec 14.
Published in final edited form as: Lab Invest. 2018 Mar 14;98(5):656–669. doi: 10.1038/s41374-018-0040-9

Figure 1. Bioluminescence imaging demonstrating dynamic changes of NFκB activity in NFκB-RE-luc reporter mice following osteoarthritis-inducing surgery.

Figure 1.

A) Images of in vivo bioluminescence imaging at multiple time points following DMM and Sham surgery on the right and left knees of the mice, respectively. As controls, left and right knees of age-matched non-surgery mice were also imaged as controls. At least 3 mice were used for each group. B) Quantification of NFκB signal detected from serial bioluminescence imaging. C) Quantification of NFκB signal detected from serial bioluminescence imaging in age-matched non-surgery controls. For statistics, ANOVA analysis was conducted, followed by Bonferroni post-hoc test. The value at 1-week post-surgery was significantly higher than those of 3- and 7-weeks post-DMM. Additionally, the value at 3 weeks in the DMM sample was significantly higher than that of the Sham. * denotes p ≤ 0.05.