. Author manuscript; available in PMC: 2021 Mar 1.

Published in final edited form as: J Acquir Immune Defic Syndr. 2020 Mar 1;83(3):267–277. doi: 10.1097/QAI.0000000000002255

Table 3.

Biomarker factor correlates of airflow limitation (3A), mosaic attenuation (3B), and combined mosaic attenuation and airflow obstruction outcome [representing obliterative bronchiolitis] (3C)

3A. Biomarker factor correlates of airflow limitation, multivariable linear regression analyses
Serum biomarkers^*	Multivariable model (β, 95% CI)	p-value	Multivariable model adjusted for age and sex (β, 95% CI)	p-value
Factor 1 – Inflammation (SAA, IL-6, CRP, sTREM-1)	−0.15 (−0.50 – 0.21)	0.41	−0.34 (−0.77 – 0.10)	0.13
Factor 2 – Endothelial and innate immune activation (sCD163, sVCAM-1, sICAM-1, Ang-2/Ang-1 ratio)	−0.42 (−0.78 – −0.06)	0.02	−0.56 (−0.92 – −0.21)	0.003
Factor 3 – Endothelin-1	−0.13 (−0.53 – 0.27)	0.51	−0.12 (−0.56 – 0.31)	0.57
Factor 4 – sCD14	−0.36 (−0.72 – 0.01)	0.06	−0.30 (−0.60 – 0.00)	0.05
3B. Biomarker factor correlates of mosaic attenuation, multivariable logistic regression analyses
Serum biomarkers^*	Multivariable model (OR, 95% CI)	p-value	Multivariable model adjusted for age and sex (OR, 95% CI)	p-value
Factor 1 – Inflammation (SAA, IL-6, CRP, sTREM-1)	1.09 (0.60 – 1.98)	0.78	0.78 (0.39 – 1.56)	0.49
Factor 2 – Endothelial and innate immune activation (CD163, sVCAM-1, sICAM-1, Ang-2/Ang-1 ratio)	1.24 (0.68 – 2.29)	0.48	1.11 (0.58 – 2.12)	0.75
Factor 3 – Endothelin-1	1.02 (0.55 – 1.91)	0.94	1.19 (0.59 – 2.41)	0.63
Factor 4 – sCD14	1.56 (0.84 – 2.89)	0.16	1.84 (0.93 – 3.64)	0.08
3C. Biomarker factor correlates of combined mosaic attenuation and airflow obstruction outcome (representing obliterative bronchiolitis), multivariable logistic regression analyses
Serum biomarkers^*	Multivariable model (OR, 95% CI)	p-value	Multivariable model adjusted for age and sex (OR, 95% CI)	p-value
Factor 1 – Inflammation (SAA, IL-6, CRP, sTREM-1)	1.22 (0.60 – 2.48)	0.58	1.07 (0.44 – 2.60)	0.87
Factor 2 – Endothelial and innate immune activation (CD163, sVCAM-1, sICAM-1, Ang-2/Ang-1 ratio)	1.51 (0.60 – 3.80)	0.39	1.72 (0.75 – 3.92)	0.20
Factor 3 – Endothelin-1	1.31 (0.62 – 2.77)	0.47	2.05 (0.68 – 6.18)	0.74
Factor 4 – sCD14	3.42 (1.25 – 9.30)	0.02	4.47 (1.50 – 13.4)	0.007

Log₁₀-transformed biomarkers were used for factor analyses

NOTE: n = 43 for these multivariable analyses; airflow limitation = lower post-bronchodilator FEV₁/FVC z-score; airflow obstruction = post-bronchodilator FEV₁/FVC z-score < −1.64