Figure - PMC

Skip to main content

An official website of the United States government

Here's how you know

Here's how you know

Official websites use .gov
A .gov website belongs to an official government organization in the United States.

Secure .gov websites use HTTPS
A lock ( ) or https:// means you've safely connected to the .gov website. Share sensitive information only on official, secure websites.

View full-text article in PMC

. 2020 Dec 14;39:283. doi: 10.1186/s13046-020-01799-1

Search in PMC
Search in PubMed
View in NLM Catalog
Add to search

© The Author(s) 2020

Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated in a credit line to the data.

PMC Copyright notice

Fig. 1 — Identification of circular RNAs by RNA-seq analyses in human CRC samples. a The scatter plot shows the changes in circRNA expression in six paired CRC and adjacent normal tissues (ANT). CircRNAs above the top green line and below the bottom green line demonstrated a greater than 1.5-fold change between the two compared groups. b The volcano plot shows the expression profiling of circRNA between CRC and ANT. The vertical green lines refer to a 2.0-fold (log2 scaled) upregulation and downregulation, respectively. The horizontal green line corresponds to a P-value of 0.05 (−log10 scaled). The red points in the plot represent differentially expressed circRNAs with statistical significance. c Clustered heat map indicating differences in circRNA expression profiling between CRC and ANT tissues. d The number of total circRNAs identified by RNA-seq and the number of differentially expressed circRNAs. e CircRNAs were classified by categories. f Validation of the top 4 differentially expressed circRNAs in 16 paired CRC and ANT tissues by RT-qPCR. CRC, colorectal cancer; ANT, adjacent normal tissue. Data represent the mean ± SD. * P < 0.05, ** P < 0.01