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. 2020 Dec 14;39:283. doi: 10.1186/s13046-020-01799-1

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© The Author(s) 2020

Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated in a credit line to the data.

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Fig. 2 — CircRNA_0000392 is upregulated in CRC and associated with progression. a - b Relative expression of circRNA_0000392 in 40 pairs of CRC and ANT tissues measured by qRT-PCR. c ROC curve analysis of circRNA_0000392 in CRC patients. AUC values are included in the graphs. d Percentages of CRC tissues with low or high expression of circRNA_0000392 according to TNM stage. e Analysis of circRNA_0000392 expression in CRC patients according to TNM stage. f Analysis of circRNA_0000392 expression in CRC patients with or without lymph node metastasis. g Analysis of circRNA_0000392 expression in CRC patients with or without distant metastasis. h Relative expression of circRNA_0000392 in cell lines was detected by qRT-PCR. Data represent the mean ± SD. * P < 0.05, ** P < 0.01