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. 2020 Dec 14;39:283. doi: 10.1186/s13046-020-01799-1

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© The Author(s) 2020

Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated in a credit line to the data.

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Fig. 4 — Knockdown of circRNA_0000392 inhibits CRC cell proliferation and invasion. a qRT-PCR analysis of circRNA_0000392 in SW620 and RKO cells after transfection with siRNA for 48 h. b - c SW620 and RKO cell proliferation after circRNA_0000392 knockdown by siRNA was detected by WST-1 assay. d The apoptosis rate was analyzed by flow cytometry after downregulation of circRNA_0000392 in SW620 and RKO cells. (E - F) Cell migration (e) and invasion (f) were assessed by transwell assay with or without Matrigel after circRNA_0000392 knockdown in SW620 and RKO cells. Data represent the mean ± SD. * P < 0.05, ** P < 0.01