Fig. 7.

CircRNA_0000392 promotes cell proliferation and invasion through the circRNA_0000392/miR-193a-5p/PIK3R3 axis. a - b SW620 and RKO cell proliferation after transfection with circRNA_0000392 siRNA and/or miR-193a-5p inhibitor was measured by WST-1. c - d The cell migration (c) and invasion (d) capabilities were determined by Transwell assay after transfection of SW620 and RKO cells with the circRNA_0000392 siRNA and/or miR-193a-5p inhibitor. e The relative mRNA expression of PIK3R3 after transfection with circRNA_0000392 siRNA and/or miR-193a-5p inhibitor was detected by qRT-PCR. f - i The relative protein expression of PIK3R3 and the phosphorylation level of downstream pathway proteins were measured by western blot in cells transfected with the circRNA_0000392 siRNA and/or miR-193a-5p inhibitor. Data represent the mean ± SD. * P < 0.05, ** P < 0.01