Fig. 8.
Downregulation of circRNA_0000392 suppresses the growth of CRC cells in vivo. a Image of subcutaneous xenograft tumors. Nude mice were injected with 5 × 106 SW620 cells (n = 5 for each group). Tumors were extracted after 30 days. b Analysis of tumor volume of mice measured every 3 days. c Tumor weight in each group at the end of the experiment. d Histological analysis of tumor tissues by hematoxylin and eosin staining. IHC of Ki-67 and PIK3R3 in subcutaneous tumors. Scale bar, 100 μm. e The graph shows the relative signal intensity scores of KI-67 and PIK3R3. f Schematic illustration of circRNA_0000392 regulating the miR-193a-5p/PIK3R3 axis in CRC. Data represent the mean ± SD. * P < 0.05, ** P < 0.01, *** P < 0.001. Additional file 1