Table 4.

Renal function outcomes at baseline, following neoadjuvant chemotherapy, and following surgery for each treatment arm.

	Baseline	Post-chemo	Post-surgery
Arm A (aMVAC)
Measured	30	30	29
Median (range) CrCl (mL/min)	82.0 (53.7, 170.0)	75.5 (23.6, 203.0)	48.0 (25.9, 173.4)
N, CrCl < 60 mL/min	2	6	20
% (90% CI), CrCl < 60 mL/min	6.7 (1.2, 19.5)	20.0 (9.1, 35.7)	69.0 (52.1, 82.8)
N, CrCl < 30mL/min	0	1	2
% (90% CI), CrCl < 30 mL/min	0.0 (0.0, 9.5)	3.3 (0.2, 14.9)	6.9 (1.2, 20.2)
Median (range) % change from baseline	-	−1.4 (−64.5, 71.1)	−40.8 (−61.8, 17.2)
Arm B (GCa)
Measured	6	6	6
Median (range) CrCl (mL/min)	45.5 (37.0, 50.0)	48.1 (35.3, 91.4)	38.7 (18.9, 68.3)
N, CrCl < 60 mL/min	6	5	5
% (90% CI), CrCl < 60 mL/min	100 (60.7, 100.0)	83.3 (41.8, 99.1)	83.3 (41.8, 99.1)
N, CrCl < 30 mL/min	0	0	2
% (90% CI), CrCl < 30 mL/min	0.0 (0.0, 39.3)	0.0 (0.0, 39.3)	33.3 (6.3, 72.9)
Median (range) % change from baseline	-	10.6 (−4.6, 82.8)	−12.9 (−61.5, 84.6)