Fig 1. Real case scenario.

A) Outline of the case scenario for evaluation of imputation results. 802 plasma samples from 645 patients were originally measured on 10 protein expression chips per protein panel. A total of 458 proteins (444 unique proteins) were measured on the 5 panels. During quality control, one chip (out of ten chips) on the inflammation panel (chip number 7) was identified to be of low quality. This chip was imputed and subsequently remeasured for evaluation, allowing for direct comparison of imputed versus remeasured values. B) Venn diagram representing the number of unique proteins as well as the overlap of protein sets measured by each of the 5 PEA panels. C) NPX values from IL-6 on the immune response panel versus the inflammation panel, revealing a malfunctioning inflammation chip (chip No. 7). D) Remeasurement of chip No. 7 resolved the quality issues.