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. 2020 Dec 14;17(12):e1003397. doi: 10.1371/journal.pmed.1003397

Fig 3. Predicted levels of NNRTI PDR in South Africa 2005–2040.

Fig 3

DTG is introduced in 2020 under 3 scenarios: DTG as first-line regimen for ART-initiators (panel A), DTG for all patients (panel B) or DTG for all patients, assuming an impact of NRTI resistance on DTG-efficacy (panel C), and with different eligibility criteria for women (colors). The baseline model shows the situation without the introduction of DTG (black line). The 2 boxes on the right of each panel represent the levels of NNRTI PDR in 2040 and their 95% sensitivity ranges. ART, antiretroviral therapy; DTG, dolutegravir; NNRTI, non-nucleoside reverse transcriptase inhibitor; NRTI, nucleoside reverse-transcriptase inhibitor; PDR, pretreatment drug resistance.