Table 3. Predictors of accurate empirical therapy of the index ESBL-UTI episode.
| Predictora | Univariate analysis | Multivariate analysis | ||||
|---|---|---|---|---|---|---|
| Non accurate N = 80 | Accurate N = 205 | P value | OR | 95%CI | P value | |
| Ageb | 62 [47.5–73.75] | 60 [29–72] | 0.136 | 0.994 | 0.983–1.005 | 0.296 |
| Gender | 0.002 | 0.037 | ||||
| • Female | 30 (37.5) | 119 (58) | Ref. | |||
| • Male | 50 (62.5) | 86 (42) | 0.528 | 0.289–0.963 | ||
| Comorbidity | 0.520 | |||||
| • No | 20 (25) | 44 (21.5) | ||||
| • Yes | 60 (75) | 161 (78.5) | ||||
| Interval between paired isolates (months)b | 3 [2–5] | 3 [2–5] | 0.673 | |||
| Reasons of admission | 0.001 | 0.018 | ||||
| • Medical reasons | 55 (68.8) | 176 (85.9) | Ref. | |||
| • Surgical reasons | 25 (31.3) | 29 (14.1) | 0.451 | 0.234–0.870 | ||
| Presence of urological/surgical condition | 0.084 | 0.839 | ||||
| • No | 35 (43.8) | 113 (55.1) | Ref. | |||
| • Yes | 45 (56.3) | 92 (44.9) | 0.939 | 0.511–1.725 | ||
| Negative Intervening culture | 0.288 | |||||
| • No | 72 (90) | 192 (93.7) | ||||
| • Yes | 8 (10) | 13 (6.3) | ||||
| Type of ESBL producer | 0.591 | |||||
| • E. coli | 65 (81.3) | 172 (83.9) | ||||
| • K. pneumoniae | 15 (18.8) | 33 (16.1) | ||||
Abbreviations: OR, odds ratio; CI, confidence interval.
a All data expressed as n (%) of participants unless otherwise indicated.
b Data described as median [Interquartile range].