Table 2:
Pathways found to be associated with sarcoidosis in publications of the last two years
| Pathway | Study type | Highlighted citation* |
|---|---|---|
| Antigen presentation via HLA | Multiple | [11, 25, 26] |
| Barrier function | GWAS | [11] |
| Interferon or TNFa signaling | WES, ml-SOM | [16, 18, 21] |
| Bacterial defense | WES | [16] |
| IL-10 signaling | WES | [16] |
| Immune cell proliferation | WES | [16] |
| Vesicle-mediated transport | WES | [16] |
| Autophagy | WES | [18] |
| Leptin signaling | WES | [18] |
| mTOR signaling | WES | [18] |
| TCA cycle | WES | [18] |
| Immune/inflammatory response | ml-SOM | [21] |
| (Positive) regulation of cell proliferation | GxE (smoking) | [25] |
| (Positive) Regulation of gamma-aminobutyric acid secretion | GxE (smoking) | [25] |
| Adenylate cucles-inhibiting G-protein coupled receptor signaling pathway | GxE (smoking) | [25] |
| Canonical Wnt signaling pathway | GxE (smoking) | [25] |
| Cell motility | GxE (smoking) | [25] |
| Cell-cell signaling by Wnt | GxE (smoking) | [25] |
| Feeding behavior | GxE (smoking) | [25] |
| Localization of cell | GxE (smoking) | [25] |
| Locomotion | GxE (smoking) | [25] |
| Non-canonical Wnt signaling pathway | GxE (smoking) | [25] |
| Peptidyl-tyrosine autophosphorylation | GxE (smoking) | [25] |
| Positive regulation of biological process | GxE (smoking) | [25] |
| Positive regulation of cellular metabolic process | GxE (smoking) | [25] |
| Positive regulation of cellular process | GxE (smoking) | [25] |
| Positive regulation of macromolecule biosynthetic process | GxE (smoking) | [25] |
| Positive regulation of macromolecule metabolic process | GxE (smoking) | [25] |
| Positive regulation of neurotransmitter transport | GxE (smoking) | [25] |
| Positive regulation of nitrogen compound metabolic process | GxE (smoking) | [25] |
| Positive regulation of nucleobase-containing compound metabolic process | GxE (smoking) | [25] |
| Regulation of animal organ morphogenesis | GxE (smoking) | [25] |
| Regulation of cell migration | GxE (smoking) | [25] |
| Response to hormone | GxE (smoking) | [25] |
| Response to nitrogen compound | GxE (smoking) | [25] |
| Response to organic substance | GxE (smoking) | [25] |
| Response to organonitrogen compound | GxE (smoking) | [25] |
| Signaling | GxE (smoking) | [25] |
| Wnt-signaling pathway | GxE (smoking) | [25] |
| Immunity | Genome-wide methylation studies | [30] |
| NLRP3 inflammasome | RT-PCR | [49] |
| Proteasome apparatus | RT-PCR | [49] |
| Ribosome biogenesis | RT-PCR | [49] |