Figure 7.

Free energy profiles of the studied exit/entry pathways from the dopamine receptor’s ligand-binding cavity. (A) Pathway in which dopamine translocates from the water phase to the bilayer center (black in Figure 6). (B) Pathway in which dopamine exits the receptor’s ligand-binding site directly into the bulk water phase (blue in Figure 6). (C) Pathway in which dopamine exits the receptor’s ligand-binding site via the membrane (red dotted line in Figure 6).