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. 2020 Nov 12;142(47):20216–20231. doi: 10.1021/jacs.0c10701

Scheme 2. Model Compounds Used in This Study and Their Experimentally Observed Acceptance by Wild-Type AMDase.

Scheme 2

The pro-(R) carboxylate is shown in black, and the pro-(S) carboxylate is shown in red. Shown here are also the specific activities for each compound (U mg–1), based on data presented in refs (15, 18, 34, and 35). We note that 1d is fully not converted (n.c.) by AMDase, wherease 1e is converted, but with very low conversion efficiency as shown in Table 1.