Figure 3.

Impact of mitral regurgitation severity on all-cause mortality in patients with mitral annular calcification-related mitral valve dysfunction according to transmitral gradient. Among patients with mitral annular calcification-related mitral valve dysfunction, adjusted Cox regression survival curves are shown stratified by mitral regurgitation severity within each transmitral gradient group (3–5, 5–10, and ≥10 mmHg). In the low-gradient group (3–5 mmHg), increasing mitral regurgitation severity was associated with worse outcome, while among patients with gradient 5–10 mmHg, only severe mitral regurgitation was associated with increased mortality. In the high (≥10 mmHg) gradient group, by contrast, mitral regurgitation severity was not associated with outcome.