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In mitral annular calcification-related mitral valve dysfunction, the mean transmitral gradient is associated with increased mortality after adjustment for age, sex, and mitral annular calcification-associated risk factors such as hypertension, diabetes, coronary artery disease, and chronic kidney disease. CAD, coronary artery disease; CKD, chronic kidney disease; MAC, mitral annular calcification; LA, left atrium; LV, left ventricle; RA, right atrium; RV, right ventricle.
