Table 2.

Impact of the mitral valve gradient on mortality in univariable and multivariable Cox model analyses

Analysis	n	HR of death (per mmHg increase in transmitral gradient)	P-value
Univariate analysis	5754	1.048 (95% CI 1.033–1.063)	<0.001
Model 1: adjusted for age and sex	5754	1.067 (95% CI 1.052–1.083)	<0.001
Model 2: Model 1 + hypertension, diabetes, CAD, and CKD	5754	1.064 (95% CI 1.049–1.080)	<0.001
Model 3: Model 2 + LV ejection fraction, severity of AS, RVSP, and atrial fibrillation	4448	1.041 (95% CI 1.024–1.059)	<0.001

AS, aortic stenosis; CAD, coronary artery disease; CKD, chronic kidney disease; LV, left ventricle; RVSP, right ventricular systolic pressure.