Table 2.
Effect of HNK on the hepatic injury-related biomarkers of the tested mice.
| Biomarker | MCS | MCD | HNK (mg/kg) | |
|---|---|---|---|---|
| 10 | 20 | |||
| Serum ALT (U/L) | 8.59 ± 1.13 | 41.42 ± 9.38## | 17.88 ± 6.39##,∗∗ | 12.76 ± 1.32##,∗∗ |
| Serum AST (U/L) | 21.37 ± 3.98 | 40.32 ± 6.23## | 32.32 ± 7.52##,∗ | 31.94 ± 4.8##,∗ |
| Hepatic TC (mmol/gprot) | 0.09 ± 0.02 | 0.19 ± 0.04## | 0.06 ± 0.02∗∗ | 0.05 ± 0.01∗∗ |
| Hepatic TG (mmol/gprot) | 0.17 ± 0.04 | 0.35 ± 0.05## | 0.28 ± 0.05## | 0.25 ± 0.05##,∗ |
| Hepatic MDA (nmol/mgprot) | 0.91 ± 0.24 | 6.15 ± 1.48## | 3.92 ± 0.72##,∗ | 3.86 ± 0.99##,∗ |
| Hepatic CAT (U/mgprot) | 22.56 ± 2.42 | 8.98 ± 1.22## | 22.56 ± 2.21∗∗ | 19.97 ± 2.75∗∗ |
| Hepatic GSH-Px (U/mgprot) | 324.39 ± 42.04 | 189.57 ± 23.68## | 236.69 ± 44.55##,∗ | 320.86 ± 47.75∗∗ |
| Hepatic HO-1 (ng/mL) | 3.42 ± 0.41 | 1.13 ± 0.24## | 5.03 ± 0.13∗∗ | 6.23 ± 0.10∗∗ |
n = 8. #p < 0.05 and ##p < 0.01vs. the MCS group; ∗p < 0.05 and ∗∗p < 0.01vs. the MCD group.