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. 2020 Dec 14;153(1):e202012747. doi: 10.1085/jgp.202012747

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© 2020 Meizoso-Huesca and Launikonis

This article is distributed under the terms of an Attribution–Noncommercial–Share Alike–No Mirror Sites license for the first six months after the publication date (see http://www.rupress.org/terms/). After six months it is available under a Creative Commons License (Attribution–Noncommercial–Share Alike 4.0 International license, as described at https://creativecommons.org/licenses/by-nc-sa/4.0/).

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Figure 6. — Effect of BTP2 on electrically evoked SR Ca²⁺ release. (A) Original recordings of mechanically skinned fibers exposed to increasing concentrations of BTP2 (i–v) obtained with confocal line scanning parallel to the fiber long axis. Ca²⁺ transients were normalized to the maximum peak value of rhod-2 fluorescence during electrical stimulation. (B) Mean of transient amplitude over time (n = 4–7). Data are presented as mean ± SD. Horizontal lines (color matched to [BTP2]) indicate where multiple t tests performed using the Holm-Sidak method revealed a significant decrease compared with 0 µM BTP2 treatment (***, P < 0.005).