Table 2. Grade 3/4 toxicities during tandem HDCT/auto-SCT.
| Parameters | First HDCT/auto-SCT (n = 20) | Second HDCT/auto-SCT (n = 18) | |
|---|---|---|---|
| Hematologic toxicity | |||
| CD34+ cells, × 106/kg | 21.4 (1.4–131.3) | 18.7 (1.8–86.5) | |
| Time (days) to reach an ANC 0.5 × 109/La | 9 (7–11) | 9 (7–12) | |
| Time (days) to reach a PLT count 20 × 109/La,b | 19 (7–66) | 20 (13–77) | |
| Days of BT ≥ 38.0°C | 4 (0–13) | 2 (0–9) | |
| Positive blood culture | 1 (5.0) | 2 (11.1) | |
| Non-hematologic toxicity | |||
| Stomatitis | 10 (50.0) | 0 (0) | |
| Vomiting | 2 (10.0) | 3 (16.7) | |
| Diarrhea | 10 (50.0) | 10 (55.6) | |
| Elevation of liver enzymes | 15 (75.0) | 1 (5.6) | |
| Hyperbilirubinemia | 0 (0) | 0 (0) | |
| Renal insufficiency | 0 (0) | 1 (5.6) | |
| Hypokalemia | 4 (20.0) | 3 (16.7) | |
| Hyperkalemia | 0 (0) | 3 (16.7) | |
| Hyponatremia | 0 (0) | 0 (0) | |
| Hypernatremia | 0 (0) | 1 (5.6) | |
| Seizure | 3 (15.0) | 0 (0) | |
| Hepatic VOD | 2 (10.0) | 2 (11.1) | |
| Myocarditis | 0 (0) | 0 (0) | |
| Treatment-related mortality | 0 (0) | 2 (11.1) | |
Data are presented as median (range) or number (%).
ANC = absolute neutrophil count, PLT = platelet, BT = body temperature, VOD = hepatic veno-occlusive disease.
aThe first day when ANC exceeded 0.5 × 109/L for 3 consecutive days; bThe first day when PLT count exceeded 20 × 109/L without transfusion for 7 days.