Table 4.

Comparison of Handheld Optical Coherence Tomography Angiography Vascular Quantification Results Between Preterm Infants with and without Advanced Retinopathy of Prematurity^a

	Preterm Infants with		Preterm Infants without
	Advanced ROP		Advanced ROP
Handheld SS-OCTA Findings	(n = 12)		(n = 142)		P Value
Vessel area density, mean (SD)
Temporal small quadrant	n = 2	0.25 (0.07)	n = 40	0.34 (0.10)	0.203
Nasal small quadrant	n = 6	0.28 (0.10)	n = 45	0.34 (0.11)	0.402
Temporal large quadrant	n = 1	0.34 (NA)	n = 19	0.40 (0.08)	NA
Nasal large quadrant	n = 3	0.62 (0.26)	n = 38	0.40 (0.10)	0.007
Nonperfusion area, mean (SD), mm2
Temporal small quadrant	n = 2	1.71 (0.24)	n = 40	1.50 (0.22)	0.274
Nasal small quadrant	n = 6	1.71 (0.23)	n = 45	1.48 (0.27)	0.279
Temporal large quadrant	n = 1	5.85 (NA)	n = 19	5.78 (0.71)	NA
Nasal large quadrant	n = 3	5.00 (1.17)	n = 38	5.82 (0.79)	0.083
Large-vessel diameter,b mean (SD), µm	n = 3	63.22 (11.0)	n = 28	63.32 (5.82)	0.893
Large-vessel tortuosity,c mean (SD)	n = 3	1.15 (0.03)	n = 28	1.15 (0.05)	0.944

n indicates the number of quadrants after eliminating quadrants of inadequate quality and merging results of superior and inferior quadrants from 1 infant with advanced ROP and 7 infants without advanced ROP. NA, not applicable since P value cannot be calculated due to limited data; the bold and italic value in the table indicates the two-side P value less than 0.05.

^aAdvanced ROP defined as stage 3 and/or pre-plus or worse ROP.

^bCalculated from large vessels of entire en face image as previously described.⁵³

^cRatio of the length of the curve of a large-vessel segment over the distance between two ends of the curve.⁵⁴