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. 2020 Dec 14;61(14):12. doi: 10.1167/iovs.61.14.12

Figure 2.

Figure 2.

Effect of Topical ocular administration of AKB-9778 on IOP in ocular normotensive New Zealand White rabbits. (A) Daily mean changes in IOP relative to vehicle control. Decreases in IOP following topical ocular (TO) administration of 4.0% AKB-9778 QD or BID persisted 24 hours postdose (day 8). (B) The calculated area under the curve for IOP values (IOP AUC) over 7 days of 4.0% AKB-9778 QD or BID was statistically significantly lower than the IOP AUC values for the vehicle control (vehicle) or 1.5% AKB-9778 BID or 10 mg/kg subcutaneous AKB-9778 BID. n = 5/group; * P ≤ 0.05 vs. vehicle; ** P ≤ 0.01 vs. vehicle; # P ≤ 0.05 vs. AKB 1.5% BID; ## P ≤ 0.001 vs. AKB 1.5% BID.