Table 1.

Absolute serum analyte concentrations and p-values of comparisons of those concentrations in controls and in Fontan patients, as measured by both methods (PM and TMS)

Analyte [µmol/L]	Control PM	Control PM relative SD	Control TMS	Control TMS relative SD	Control PM vs. Control TMS, p-value	Fontan PM	Fontan PM relative SD	Fontan TMS	Fontan TSM relative SD	Fontan PM vs. Fontan TMS, p-value
Alanine	386.2 ± 83.6	0.22	410.5 ± 119.9	0.30	0.3316	381.0 ± 75.0	0.20	401.4 ± 82.0	0.21	0.0457
Alpha-AAA	5.3 ± 3.0	0.38	0.77 ± 0.43	0.57	6.2E−07	3.9 ± 2.4	0.39	1.12 ± 0.6	0.55	6.8E−07
Arginine	95.7 ± 18.1	0.19	108.3 ± 21.2	0.20	0.0038	86.4 ± 29.9	0.35	91.7 ± 26.1	0.29	0.0353
Aspartic acid	16.2 ± 8.2	0.14	17.2 ± 6.8	0.16	5.4E−07	16.9 ± 9.3	0.19	18.1 ± 10.2	0.18	1.5E−10
Asparagine	65.8 ± 9.4	0.42	50.7 ± 7.8	0.40	0.5224	56.4 ± 10.8	0.55	43.7 ± 7.5	0.58	0.7544
Citrulline	33.8 ± 6.8	0.20	29.2 ± 6.4	0.23	6.3E-05	33.4 ± 7.6	0.23	29.4 ± 6.1	0.21	0.0002
Glutamine	583.0 ± 69.8	0.12	749.0 ± 108.9	0.15	3.4E−07	565.1 ± 98.9	0.18	717.4 ± 130.7	0.19	3.4E−07
Glutamic acid	42.3 ± 18.9	0.45	46.9 ± 31.3	0.46	0.5036	83.4 ± 65.9	0.79	85.9 ± 61.8	0.74	0.2565
Glycine	251.4 ± 51.2	0.20	345.3 ± 89.4	0.27	3.7E−08	243.2 ± 47.3	0.19	321.6 ± 72.2	0.23	4.7E−08
Histidine	93.2 ± 10.6	0.11	110.4 ± 23.8	0.22	0.0033	81.1 ± 12.6	0.16	93.08 ± 14.6	0.16	0.0013
t4-OH-Pro	19.2 ± 13.2	0.61	11.7 ± 5.1	0.45	0.0822	20.9 ± 12.2	0.52	15.8 ± 4.9	0.32	0.0438
Isoleucine	64.9 ± 18.2	0.28	100.9 ± 38.5	0.39	4.8E−06	69.7 ± 19.2	0.28	106.6 ± 30.8	0.30	6.5E−10
Leucine	135.6 ± 31.1	0.23	232.8 ± 103.9	0.46	3.4E−07	131.2 ± 34.5	0.26	222.9 ± 76.6	0.35	1.5E−10
Lysine	178.2 ± 29.2	0.16	165.8 ± 31.6	0.20	0.0080	179.5 ± 29.8	0.17	168.1 ± 22.9	0.14	0.0147
Methionine	28.9 ± 6.0	0.21	29.4 ± 7.6	0.27	0.9212	27.8 ± 8.3	0.30	27.9 ± 8.1	0.30	0.9733
Ornithine	86.7 ± 22.6	0.26	111.6 ± 39.9	0.37	2.2E−05	103.3 ± 34.6	0.33	139.4 ± 80.2	0.59	0.0003
Phenylalanine	68.1 ± 10.9	0.16	76.9 ± 12.5	0.17	0.0085	69.3 ± 11.8	0.17	77.7 ± 16.5	0.22	0.0029
Proline	235.2 ± 58.5	0.25	265.7 ± 60.1	0.23	0.0005	226.0 ± 56.0	0.25	259.4 ± 62.1	0.25	1.3E−05
Serine	132.0 ± 19.5	0.15	146.5 ± 23.1	0.16	0.0129	136.6 ± 21.2	0.16	158.4 ± 32.3	0.21	0.0005
Taurine	141.2 ± 50.6	0.36	132.6 ± 55.1	0.43	0.2413	109 ± 51.5	0.47	100.4 ± 55.7	0.57	0.0002
Threonine	148.3 ± 30.4	0.21	127.3 ± 27.7	0.22	1.3E−04	132.6 ± 26.4	0.20	105.6 ± 20.5	0.20	0.0000
Tryptophane	86.4 ± 22.1	0.26	89.5 ± 22.7	0.26	0.5899	89.5 ± 22.4	0.25	90.5 ± 19.7	0.22	0.7814
Tyrosine	78.3 ± 22.5	0.20	83.6 ± 18.9	0.23	0.4115	77.5 ± 19.5	0.25	87.0 ± 22.5	0.26	0.0005
Valine	254.2 ± 49.0	0.19	290.7 ± 74.9	0.26	0.0193	257.8 ± 54.6	0.21	298.9 ± 70.6	0.24	0.0002

Serum values of controls and Fontan patients are given as mean ± standard deviation (relative standard deviation). p < 0.05 is printed in bold letters. Alpha-AAA, alpha-aminoadipic acid; t4-OH-Pro, trans-4-hydroxyproline