Figure 7A, B and C.

KU757 treatment of WRO-LvR downregulates the glycolytic and oncogenic lncRNAs present in exosomes. Exosomes were isolated by standard ultracentrifugation method. Nanoparticle analysis by NTA (Figure 7A) and Western Blot for Alix, CD9 (Figure 7B) show the purity of exosomes. LncRNA analysis of exosomes was performed by RT-PCR to evaluate differentially expressed lncRNAs (Figure 7C). TUG1 and UCA1 (marked with (***)) regulate the expression of HK2 and PKM2 that are involved in glycolysis.