Table 1:
Active (6% NaCl) (n=14) | Placebo (0.12% NaCl) (n=9) | All subjects (n = 23) | |
---|---|---|---|
Female, % | 8 (57%) | 4 (44%) | 12 (52%) |
Age, years (SD) | 11.9 (3.3) | 9.8 (3.6) | 11.1 (3.5) |
Post-BD FVC, % predicted (SD) | 101.4 (12.3) | 100.0 (10.9) | 100.8 (11.5) |
Post-BD FEV1, % predicted (SD) | 97.0 (12.6) | 93.2 (13.4) | 95.5 (12.8) |
Post-BD FEF25–75, % predicted (SD) | 91.1 (24.9) | 86.2 (37.8) | 89.7 (27.9) |
Inhaled antibiotics (%) | 2 (14%) | 1 (11%) | 3 (13%) |
Chronic HS (%) | 1 (7%) | 3 (33%) | 4 (17%) |
Dornase Alfa (%) | 3 (36%) | 4 (44%) | 9 (39%) |
Pancreatic Sufficient (%) | 0 (0%) | 1 (11%) | 1 (4%) |
Abbreviations: SD – Standard Deviation, BD – bronchodilator, FVC – forced vital capacity, FEV1 – Forced Expiratory Volume in 1 second, FEF25–75 - Forced expiratory flow 25–75%. No subjects used CFTR modulators during this study.