TABLE 4.
Proteins in the E category (Amino acid transport and metabolism) modulated during P. freudenreichii growth in soy ultrafiltrate compared to cow’s milk ultrafiltrate.
| Accession | Description(a) | Ratio(b) | Adjusted p-value |
| CDP48506.1 | Alanine dehydrogenase | 14.38 | 3.6E-17 |
| CDP48507.1 | D-serine/D-alanine/glycine transporter | 8.85 | 2.1E-11 |
| CDP49406.1 | Glycine cleavage system T protein, aminomethyltransferase | 2.95 | 9.9E-15 |
| CDP47584.1 | Tryptophan synthase beta subunit | 2.81 | 1.4E-08 |
| CDP47878.1 | ATP-binding protein opuCA of Glycine betaine/carnitine/choline ABC transporter | 2.45 | 8.3E-11 |
| CDP49183.1 | iolD (Myo-inositol catabolism iolD protein) (acetolactate synthase protein) [pyruvate:pyruvate acetaldehydetransferase (decarboxylating)] | 2.19 | 1.1E-07 |
| CDP47555.1 | Argininosuccinate lyase (Arginosuccinase) | 2.18 | 6.5E-04 |
| CDP49472.1 | ABC-type choline/glycine betaine transport, ATP-binding protein | 2.14 | 4.1E-04 |
| CDP49746.1 | Delta 1-pyrroline-5-carboxylate reductase | 2.11 | 3.1E-03 |
| CDP49146.1 | L-asparaginase I | 1.93 | 2.0E-07 |
| CDP48778.1 | Branched-chain amino acid aminotransferase | 0.66 | 4.3E-03 |
| CDP48362.1 | Monophosphatase | 0.66 | 9.5E-06 |
| CDP49745.1 | Aspartate-semialdehyde dehydrogenase (Semialdehyde dehydrogenase) | 0.64 | 1.5E-07 |
| CDP48347.1 | Diaminopimelate decarboxylase (DAP decarboxylase) | 0.58 | 1.1E-05 |
| CDP48645.1 | Indole-3-glycerol phosphate synthase (TrpC) | 0.54 | 2.2E-08 |
| CDP49386.1 | Phospho-2-dehydro-3-deoxyheptonate aldolase | 0.50 | 7.2E-10 |
| CDP49437.1 | 2,3,4,5-tetrahydropyridine-2,6-dicarboxylate N-succinyltransferase | 0.49 | 1.4E-06 |
| CDP48372.1 | Binding protein of oligopeptide ABC transporter (OPN : undef : Oligopeptides) | 0.46 | 1.5E-05 |
| CDP49173.1 | Dihydroxy-acid dehydratase | 0.44 | 2.4E-10 |
| CDP48366.1 | D-3-phosphoglycerate dehydrogenase/erythronate 4-phosphate dehydrogenase | 0.43 | 9.1E-08 |
| CDP47871.1 | Chorismate mutase | 0.43 | 2.5E-03 |
| CDP48150.1 | Threonine dehydratase | 0.42 | 8.0E-04 |
| CDP48503.1 | Amidohydrolase (Peptidase M20D) (Putative metal-dependent amidase/aminoacylase/carboxypeptidase) | 0.42 | 1.7E-07 |
| CDP47573.1 | Phosphoribosyl-ATP pyrophosphohydrolase | 0.42 | 1.8E-02 |
| CDP48773.1 | 3-isopropylmalate dehydratase large subunit (Isopropylmalate isomerase) (Alpha-IPM isomerase) (IPMI) | 0.38 | 9.1E-06 |
| CDP49606.1 | Shikimate 5-dehydrogenase | 0.38 | 1.4E-08 |
| CDP48647.1 | Phosphoribosyl-AMP cyclohydrolase | 0.37 | 9.2E-12 |
| CDP49001.1 | Glutamate dehydrogenase [NAD(P)-glutamate dehydrogenase] | 0.37 | 2.1E-06 |
| CDP48467.1 | Propanediol utilization protein PduJ | 0.35 | 7.2E-06 |
| CDP48419.1 | 4-aminobutyrate aminotransferase | 0.29 | 2.9E-14 |
| CDP49308.1 | Cysteine desulphurases, SufS | 0.22 | 1.0E-15 |
| CDP49551.1 | DadA, Glycine/D-amino acid oxidases | 0.22 | 3.6E-08 |
| CDP49535.1 | Cysteine synthase 2 | 0.19 | 7.2E-14 |
| CDP48772.1 | 3-isopropylmalate dehydratase small subunit (Isopropylmalate isomerase) (Alpha-IPM isomerase) (IPMI) | 0.19 | 2.2E-10 |
| CDP48346.1 | Homoserine dehydrogenase | 0.17 | 3.5E-10 |
(a)Determined using a database composed of the proteome of P. freudenreichii CIRM-BIA129 (downloaded from NCBI.nlm.nih.gov on 23 August 2018). (b)Ratio between the protein level in soy ultrafiltrate and in cow’s milk ultrafiltrate. This ratio indicates induction (ratio > 1.5) or repression (ratio < 0.66) during growth in soy ultrafiltrate.