Table 3.
Example of SLP and ELP sequences, structures, formulations, and applications.
| Structure | Sequence Modifications | Material Format | Applications | Reference |
|---|---|---|---|---|
| Silkworm silk | ||||
| GAGAGS | Elastin GXGVP X is any amino acid except Pro |
Nanoparticles | Drug delivery (doxorubicin) | [140,161,162] |
| Elastin GXGVP X is Valine |
Hydrogels | Gene delivery | [160] | |
| Spider silk | Poly-lys | Particles (pDNA complexes) | Gene delivery | [20,73] |
| ECM peptides (RGD) Cell penetrating peptides |
Particles (pDNA complexes) | Gene delivery | [77] | |
| Tumor-homing peptides | Particles | Gene delivery | [78,79] | |
| Nuclear localization sequence and translocation motifs | Nanoparticles | Delivery of Cy-5-labeled pDNA | [82] | |
| Elastin | ||||
| GXGVP | X is Valine | Nanoparticles | Delivery of bone morphogenic proteins | [108] |
| X is Valine | Hydrogels | Delivery of antibiotics and proteins | [120] | |
| X is any amino acid except proline | Nanoparticles, microgels | Delivery of Doxorubicin, rhodamine | [109,111] | |
| X is Lysine | Microspheres | Delivery of BSA and prednisone acetate | [112] | |
| X is polyaspartic acid | Particles | Delivery of hydrophobic fluorescent molecules | [95] | |
| Bioengineered with polyaspartic acid | Nanoparticles | Delivery of Paclitaxel | [110] | |
| X is Valine Bioengineered with VEGF and kidney-targeting peptide |
Soluble protein | Delivery of VEGF in kidney | [98] | |
| X is Alanine | Nanoparticles | Delivery of antibody Rituximab | [100] |