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. Author manuscript; available in PMC: 2021 Mar 13.
Published in final edited form as: Mucosal Immunol. 2020 Jun 15;14(2):317–330. doi: 10.1038/s41385-020-0312-8

Figure 9. ILC2 responses to IL-33 in Ffar2−/− mice with or without regulation of SCFA levels.

Figure 9.

(a) WT and Ffar2−/− mice were injected i.p. with IL-33 (500 ng per injection) or PBS control for three consecutive days, and ILC numbers in indicated tissues were examined 36h later. (b) Frequency of ILC2P in the bone marrow (BM). (c) Combined data showing ILC numbers in indicated tissues. (d) Impact of SCFAs on the ILC2 response to IL-33 in WT versus Ffar2−/− mice. For panel e, mice were fed LFD for 2 weeks and then fed SCFA water for 1 week prior to IL-33 injection (3 times). The data were obtained from 2 independent experiments using total 4 mice each group. *Significant differences (p<0.05) from WT.