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. Author manuscript; available in PMC: 2022 Jan 1.
Published in final edited form as: Mol Cell Endocrinol. 2020 Oct 14;519:111052. doi: 10.1016/j.mce.2020.111052

Figure 3: The growth-plate.

Figure 3:

The effects of the GH/IGF axis on chondrocytes of the growth plate were extensively studied (and described in the current review). GH elicits direct and IGF-dependent effects on chondrocytes in all zones of the growth plate. However, IGF-1 actions were mostly detected at the proliferative zone, while those of GH were localized to the germinal zone.