Skip to main content
. Author manuscript; available in PMC: 2022 Jan 1.
Published in final edited form as: Neurobiol Aging. 2020 Oct 1;97:18–27. doi: 10.1016/j.neurobiolaging.2020.09.019

Figure 2. Chicago plot for the association between cis-mQTLs and DNA methylation.

Figure 2.

We identified a total of 370,257,499 cis- mQTL SNPs at P < 0.05 using the R package “MatrixEQTL”. In the plot, we only kept the cis- mQTL SNP having the smallest P-value for a CpG in the cases of multiple SNPs associated with the same CpG. Each point represents the association of a cis- mQTL SNP. The horizontal coordinate represents the location of a CpG within the chromosome, and the vertical coordinate is –log10 (P-value) if the association is positive and log10 (P-value) if the association is negative. The dashed line corresponds to the significance level using Bonferroni correction (1.35×10−10).