Table 2.

Associations of the outcome of sensitivity loss ≥ 6dB during treatment with predictor variables including locus characteristics and participant cohort, using data of loci with baseline sensitivity ≥ 6 dB (total N = 1613 such loci)

	Observed No. of events/Total No. of loci (%)	Bivariable model		Multivariable model
		Unadjusted ORs (95%CI)	p-value*	Adjusted ORs (95%CI)	p-value*
Participant cohort			.004		.033
C1	67/427 (15.69)	Ref		Ref
C2	28/536 (5.22)	0.27 (0.13, 0.59)		0.34 (0.14, 0.79)
C3	24/650 (3.69)	0.28 (0.09, 0.86)		0.33 (0.11, 1.02)
Locus own baseline sensitivity			.019		.034
>12 dB	48/990 (4.85)	Ref		Ref
> 8 and ≤ 12dB	34/358 (9.50)	1.63 (1.15, 2.31)		1.56 (1.02, 2.39)
>6 and ≤ 8dB	37/265 (13.96)	1.68 (1.08, 2.59)		1.62 (1.03, 2.54)
Whether the locus neighbored a locus with 0 dB baseline sensitivity			.047		.29
No	77/645 (11.94)	Ref		Ref
Yes	42/968 (4.34)	0.68 (0.46, 1.00)		0.78 (0.49, 1.24)
Eccentricity of locus**			.18
Perifoveal	71/1030 (6.89)	Ref		N/A
Parafoveal	35/397 (8.82)	0.60 (0.35, 1.04)
Foveal	13/186 (6.99)	0.93 (0.67, 1.30)
Hemisphere			.32
Superior	53/811 (6.54)	Ref		N/A
Inferior	66/802 (8.23)	0.81 (0.53, 1.22)
Nasal vs. Temporal			.47
Nasal	54/753 (7.17)	Ref		N/A
Temporal	65/860 (7.56)	1.09 (0.86, 1.39)

N/A: not applicable because the variable was not included in the multivariable regression model since its univariate association had p>0.10.

^*:the p-value is for testing whether there was any significant difference in the outcome event probability comparing the different groups. Wald test results were used.

^**:Fovea: loci located on the ring of 2° eccentricity. Parafovea: loci located on the ring of 4° eccentricity. Perifovea: loci located on the rings of 6° to 10° eccentricity.

(OR: odds ratio. CI: confidence interval).