Table 3.

Associations of the outcome of ≥ 6 dB sensitivity gain during treatment with predictor variables including locus characteristics and participant cohort.

	Observed No. of events/Total No. of loci (%)	Bivariable model		Multivariable model
		Unadjusted ORs (95%CI)	p-value*	Adjusted ORs (95%CI)	p-value*
Participant cohort			.40		.44
C1	122/1224 (9.97)	Ref		Ref
C2	53/1020 (5.20)	0.56 (0.20, 1.55)		0.56 (0.10, 3.13)
C3	112/1224 (9.15)	0.91 (0.36, 2.33)		1.40 (0.27, 7.19)
Locus own baseline sensitivity			<.001		<.001
>16dB	31/709 (4.37)	Ref		Ref
>8 and ≤16dB	55/639 (8.61)	2.22 (1.06, 4.68)		4.87 (2.30, 10.32)
>0 and ≤8dB	101/624 (16.19)	7.02 (2.53, 19.47)		17.68 (6.64,47.07)
0dB	100/1496 (6.68)	4.31 (1.01, 18.38)		13.51 (3.88, 47.06)
Whether the locus neighbored a locus with 0 dB baseline sensitivity			.22	N/A
No	193/2387 (8.09)	Ref
Yes	94/1081 (8.70)	1.46 (0.80, 2.68)
Eccentricity of locus**			.049		<.001
Perifoveal	196/2652 (7.39)	Ref		Ref
Parafoveal	66/612 (10.78)	1.74 (0.97, 3.12)		2.48 (1.73, 3.56)
Foveal	25/204 (12.25)	1.51 (1.05, 2.18)		7.37 (3.65, 14.86)
Hemisphere			.013		.005
Superior	120/1734 (6.92)	Ref		Ref
Inferior	167/1734 (9.63)	1.43 (1.08, 1.89)		1.41 (1.11, 1.80)
Nasal vs. Temporal			0.81	N/A
Nasal	146/1734 (8.42)	Ref
Temporal	141/1734 (8.13)	1.04 (0.77, 1.41)

N/A: not applicable because the variable was not included in the multivariable regression model since its univariate association had p>0.10.

^*:the p-value is for testing whether there was a significant difference in the outcome event probability comparing the different groups. Wald test results were used.

^**:Fovea: loci located on the ring of 2° eccentricity. Parafovea: loci located on the ring of 4° eccentricity. Perifovea: loci located on the rings of 6° to 10° eccentricity.

(OR: odds ratio. CI: confidence interval).