Table. 2.

TRPV4 expression and function in various tissues of the eye.

Tissue	Cell type	Function	Pathology	Reference
Corneal epithelium	Outermost layer of epithelial sheets	Formation of tight junctions Regulation of osmolarity Healing/repair	Corneal injury	Marínez-Rendón et al., 2017 Pan et al., 2008 Okada et al., 2016 Okada et al., 2019
Lens	Epithelium	Detect damage Activate Src family kinases Increase Na, K-ATPase	Lens swelling	Shahidullah et al., 2015 Shahidullah et al., 2012
	Fiber cells of outer cortex	Work in conjunction with epithelium to detect damage to fiber mass		Shahidullah et al., 2015 Nakazawa et al., 2019
Ciliary body	Nonpigmented epithelial cells	Sense osmotic changes Regulate Ca2+ signaling Aid in production of melatonin	-	Jo et al., 2016 Alkozi et al., 2017
Trabecular meshwork	-	Sense mechanical changes Ca2+ signaling Phosphorylation of FAK Restructuring of vinculin Thickening of stress fibers Trafficking TRPV4 channels to primary cilia	Glaucoma	Ryskamp et al., 2016 Luo et al., 2014
Retina	Müller cells	Sense changes in osmolarity Ca2+ release Reactive gliosis	Retinal damage from trauma	Ryskamp et al., 2014 Toft-Bertlesen et al., 2017
	Retinal endothelial cells	Regulate Ca2+ entry Aid tube formation Form heteromeric channels with TRPV1	Retinopathy Glaucoma	Wen et al., 2018 O’Leary et al., 2019
	Bipolar cells & Retinal ganglion cells	Regulate RGC firing via regulation of Ca2+ influx Cause apoptosis if continuously activated Shorten delay time of Na+ currents	Glaucoma	Gao et al., 2019 Ryskamp et al., 2011 Taylor et al., 2017 Lakk et al., 2018
	Photoreceptor cells (PRC)	Cytokine MCP-1 release from Müller cells→ apoptosis of PRC	Retinal detachment	Matsumoto et al., 2018