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. Author manuscript; available in PMC: 2021 Dec 1.
Published in final edited form as: Reprod Toxicol. 2020 Oct 28;98:260–268. doi: 10.1016/j.reprotox.2020.10.009

Table 1.

Effects of prenatal exposure to phthalate mixture on body weight, tissue weight, and occurrence of grossly visible cystic ovaries in the F3 generation of 13 month old female mice

F3 Generation
Treatment
Body Weight (g) Control 46.01 ± 3.32
20 μg/kg/day 46.73 ± 3.65
200 μg/kg/day 51.28 ± 3.58
200 mg/kg/day 49.19 ± 2.72
500 mg/kg/day 40.47 ± 2.26
Single Ovary Weight (g) Control 0.0080 ± 0.0010
20 μg/kg/day 0.0148 ± 0.0006*
200 μg/kg/day 0.0092 ± 0.0015
200 mg/kg/day 0.0118 ± 0.0019
500 mg/kg/day 0.0072 ± 0.0010
Uterine Weight (g) Control 0.2041 ± 0.0244
20 μg/kg/day 0.2337 ± 0.0228
200 μg/kg/day 0.2192 ± 0.0239
200 mg/kg/day 0.2278 ± 0.0402
500 mg/kg/day 0.2786 ± 0.0131
Liver Weight (g) Control 2.5658 ± 0.1604
20 μg/kg/day 2.7343 ± 0.1709
200 μg/kg/day 2.9306 ± 0.2055
200 mg/kg/day 2.7714 ± 0.1444
500 mg/kg/day 2.4965 ± 0.0760
AGD (mm)/∛Body Weight (g) Control 1.7313 ± 0.0665
20 μg/kg/day 1.7435 ± 0.0506
200 μg/kg/day 1.5799 ± 0.0972
200 mg/kg/day 1.6454 ± 0.0721
500 mg/kg/day 1.6727 ± 0.1193
Percent Grossly Visible Cystic Ovaries (%) Control 33.3
20 μg/kg/day 44.4
200 μg/kg/day 33.3
200 mg/kg/day 33.3
500 mg/kg/day 50.0

Asterisks (*) indicate significant differences compared to the control (p < 0.05).