Table 2:
Baseline characteristics and operative approach of cases with completed IPAA procedures, stratified by staged approach. P-values represent comparisons between Cohorts A and B.
| IPAA operations for UC
patients n=164 |
|||||
|---|---|---|---|---|---|
| Cohort A, Immediate
IPAA N=46 |
Cohort B, Delayed
IPAA N=118 |
p-value | |||
| Parameter | One Stage RPC IPAA n=5 |
Classic Two Stage
RPC-IPAA n=41 |
Modified Two Stage
RPC-IPAA n=4 |
Three Stage RPC-IPAA n=114 |
|
| Age at time of
Operation years median (IQR) |
24.3 (8.3) | 39.3 (25.4) | 40.6 (6.8) | 33.9 (20.4) | 0.493 |
| Females n (%) |
2 (40) | 21 (51) | 4 (100) | 45 (40) | 0.382 |
| White n (%) |
4 (80) | 34 (83) | 3 (75) | 96 (84) | 0.390 |
| BMI kg/m^2 mean (SD) |
23.9 (4.4) | 25.9 (5.3) | 28.0 (5.7) | 25.9 (5.1) | 0.673 |
| ASA Classification n (%) |
|||||
| ASA 1 | 0 (0) | 0 (0) | 0 (0) | 2 (1.8) | 0.684 |
| ASA 2 | 5 (100) | 26 (63.4) | 4 (100) | 65 (57) | |
| ASA 3 | 0 (0) | 15 (36.6) | 0 (0) | 46 (40.4) | |
| None assigned | 0 (0) | 0 (0) | 0 (0) | 1 (0.9) | |
| Smoker within 1 year of
operation n (%) |
0 (0) | 0 (0) | 0 (0) | 7 (6) | 0.192 |
| 10% weight loss in 6 mo. prior to
operation n (%) |
1 (20) | 2 (5) | 0 (0) | 6 (5) | 0.712 |
| Steroid use for chronic
condition n (%) |
4 (40) | 21 (51) | 1 (25) | 14 (12) | <0.001 |
| Biologic agent within 60 days prior to
operation n (%) |
3 (60) | 18 (44) | 1 (25) | 9 (8) | <0.001 |
| Immune modulator use within 60 days prior
to operation n (%) |
0 (0) | 6 (15) | 0 (0) | 3 (2.6) | 0.015 |
| Colonic Dysplasia n (%) |
|||||
| None | 4 (80) | 23 (56.1) | 4 (100) | 95 (83.3) | |
| Low grade dysplasia | 1 (20) | 7 (17.1) | 0 (0) | 2 (1.8) | <0.001 |
| High grade dysplasia | 0 (0) | 5 (12.2) | 0 (0) | 0 (0) | |
| Colorectal cancer | 0 (0) | 1 (2.4) | 0 (0) | 0 (0) | |
| Unable to determine/Not applicable | 0 (0) | 5 (12.2) | 0 (0) | 17 (14.9) | |
| Serum albumin (g/dL) mean (SD) |
4.5 (0.2) | 4.0 (0.6) | 3.9 (0.3) | 4.2 (0.4) | 0.210 |
| HCT % median (IQR) |
43.1 (7.0) | 38.6 (6.4) | 38.8 (0.9) | 40.1 (7.1) | 0.371 |
| WBC 103 per μL median (IQR) |
7.3 (4.1) | 7.4 (4.4) | 6.7 (2.4) | 7.0 (2.5) | 0.530 |
| UC operation volume, n
cases n (%) |
0.014 | ||||
| <89 | 3 (60) | 31 (75.6) | 0 (0) | 62 (54.4) | |
| 89+ | 2 (40) | 10 (24.4) | 4 (100) | 52 (45.6) | |
| Approach n (%) |
|||||
| MIS | 2 (40) | 30 (73.2) | 2 (50) | 50 (43.9) | 0.011 |
| Open | 1 (20) | 9 (22.0) | 0 (0) | 53 (46.5) | |
| Unknown | 2 (40) | 2 (4.9) | 2 (50) | 11 (9.6) | |
BMI=body mass index, ASA=American Society of Anesthesiologists, IPAA=Ileal pouch anal anastomosis, IQR=interquartile range, RPC=restorative proctocolectomy, SD=standard deviation, HCT=hematocrit, WBC=white blood cells, UC=ulcerative colitis