Table 4:

Multi-predictor model for significant predictors of greater Clavien-Dindo postoperative complication severity following IPAA formation for immediate vs. delayed pouch operation(i.e. Cohort A vs. Cohort B), respectively. Predictors, including pouch delay, in the final multi-predictor model are shown on the right.

	Single-predictor analysis				Multi-predictor analysis
Predictor	Parameter Estimate	95% CI		p-value, Between-subjects effects	Parameter Estimate	95% CI		p-value
		Lower	Upper			Lower	Upper
Immediate versus delayed pouch formation	0.34	−0.264	0.945	0.268	0.38	−0.22	0.98	0.21
Age at time of Operation, per year	0.01	−0.01	0.029	0.331
Female sex	−0.013	−0.563	0.536	0.962
White	0.08	−0.965	1.126	0.25
BMI, per kg/m^2	0.009	−0.045	0.062	0.746
ASA Classification, per class	0.489	0.023	0.954	0.04	0.51	0.042	0.97	0.033
Smoker within 1 year of operation	−0.451	−1.798	0.896	0.509
10% weight loss in 6 mo. prior to operation	0.668	−0.525	1.861	0.27
Steroid use for chronic condition	0.335	−0.297	0.968	0.297
Biologic agent within 60 days prior to operation	0.461	−0.277	1.11	0.238
Immunomodulation within 60 days prior to operation	−0.136	−1.328	1.055	0.262
Serum albumin, per g/dL	0.034	−0.642	0.709	0.921
HCT, per %	0.004	−0.049	0.057	0.88
WBC, per 10^3 per μL	0.012	−0.101	0.125	0.837
UC operative volume				0.658
<89	0.124	−0.429	0.677
89+	Reference
Colonic Dysplasia (including CRC)	0.71	−0.203	1.623	0.203
Operative approach
MIS	Reference			0.625
Open	−0.067	−0.65	0.515
Unknown	0.398	−0.53	1.327
Anastomotic Technique
Double staple	Reference
Hand sewn w/out mucosectomy	−1.179	−4.685	2.326	0.624
Mucosectomy w/ hand sew	−0.179	−1.949	1.59
Other	−1.179	−3.216	0.857
Diverting ileostomy formation	−0.08	−1.277	1.117	0.895

BMI=body mass index, ASA=American Society of Anesthesiologists, IPAA=Ileal pouch anal anastomosis, IQR=interquartile range, RPC=restorative proctocolectomy, SD=standard deviation, HCT=hematocrit, WBC=white blood cells, UC=ulcerative colitis