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. 2020 Dec 14;3:766. doi: 10.1038/s42003-020-01419-w

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© The Author(s) 2020

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 1 — a Cryo-EM structure (PDB 5LJO)¹⁵ of detergent (DDM)-solubilised BAM in the ‘lateral open’ conformation. The β-strands 1 and 16 and the lateral gate are indicated. Inset: the crystal structure (PDB 5D0O)¹³ of BAM in the ‘lateral closed’ conformation. b The conformation of the BamA β-barrel and position of POTRA5 in the ‘lateral closed’ X-ray structure (pdb 5D0O)¹³ and c ‘lateral open’ cryo-EM structure (pdb 5LJO)¹⁵. The centres of mass of POTRA5 for both conformations are marked with red (lateral closed) and green (lateral-open) spheres in each panel. d, e Bottom (periplasmic) view of the d lateral closed and e lateral-open conformations of BAM showing the different shape of the β-barrel. As in panels b and c, centres of mass for POTRA5 in both conformations are marked in each panel. POTRA domains 1–4 and the lipoproteins (BamB–E) have been removed in panels (b) through (e) for clarity.