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. 2020 Dec 14;10:21836. doi: 10.1038/s41598-020-75862-4

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© The Author(s) 2020

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.

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All lipid classes evaluated showed inverse correlation between the levels of the (A) sum of all structural lipids (Structural Lipids) (Y-axis), (B) lysophosphatidylcholine (Total LPC) (Y-axis), (C,D) phosphatidylcholine (Total PC aa and Total PC ae) (Y-axis), (E) sphingomyelin (Total SM) (Y-axis), and the prognosis of patients with MM. (F–H) showed significant decrease in the production of glucose and glutamine-dependent lipids (Y-axis) in MM patients in relation to controls (X-axis), a phenomenon that is also accentuated with the increase in ISS (p values, FDR and Fisher’s LSD in supplemental material 3).