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. 2020 Dec 14;10:21836. doi: 10.1038/s41598-020-75862-4

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© The Author(s) 2020

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.

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Serotonin (Y-axis) was significantly elevated in cases of MM, without, having a clear association between higher levels and ISS 3 (X-axis) (A). Activity of Melatonin Receptor 1 B (Trp/Phe) (Y-axis) shows significant differences between cases and controls, becoming even more evident in ISS 3 cases (X-axis) (B). Activity of dioxigenases (kynurenine/tryptophan) (Y-axis) (C) and oxidative stress (Met-SO/Met) (Y-axis) (D) demonstrate that, in addition to being significantly elevated in the cases of MM, they are even higher in the cases classified as ISS 3 (X-axis).