. 2020 Dec 14;10:21861. doi: 10.1038/s41598-020-78873-3

Table 1.

Summary of highly correlated metabolites in different biosynthetic pathways.

Biosynthetic pathways	p-value	Metabolites
Phenylpropanoid derivatives biosynthesis^a	2.56e−05	Quercetin^{a,b,c,d,e,f,g,j,q}
Superpathway of flavones and derivatives biosynthesis^b	4.65e−04	Luteolin^a,d,g,j,n
Flavonols biosynthesis^c	7.48e−04	Syringin^a,j,k
Flavonoids biosynthesis^d	1.18e−03	Kaempferol-3-glucoside^a,b,c,d,j
Rutin biosynthesis^e	2.95e−03	Rutin^a,b,c,d,e,j
Quercetin glycoside biosynthesis (Arabidopsis)^f	5.07E−03	Benzoate^a,j,m,p
Flavonoid biosynthesis (In Equisetum)^g	7.72e−03	Coniferin^a,j,k,p,r
Proteinogenic amino acids biosynthesis^h	2.26e−03	Quercetin 3-O-rhamnoside^a,b,c,d,f,j
Amino acids biosynthesis^h	6.54e−03	l-Arginine^h,i,p,s
Proteinogenic amino acids degradationⁱ	8.72e−03	l-Tryptophan^h,i,j,p
Amino acids degradationⁱ	1.07e−02	Adenine^h,l,p,t
Secondary metabolites biosynthesis^j	1.29e−02	l-Isoleucine^h,i
Lignins biosynthesis^k	2.31e−02	Adenosine^h,i,o,p,t
S-methyl-5′-thioadenosine degradation ii^l	2.59E−02	l-Isoleucine^p
Benzoyl-β-d-glucopyranose biosynthesis^m	2.59E−02
Benzoate degradation^m	3.86e−02
Benzoate degradation II (aerobic and anaerobic)^m	3.86E−02
Chrysoeriol biosynthesisⁿ	3.23e−02
Adenine and adenosine salvage VI^o	3.23E−02
Degradation/utilization/assimilation^p	3.35e−02
Methylquercetin biosynthesis^q	3.86e−02
Phenylpropanoid derivatives degradation^r	4.49e−02
Coniferin metabolism^r	4.49e−02
Putrescine biosynthesis I^s	4.49E−02
Adenine and adenosine salvage II^t	8.13E−04
Adenine and adenosine salvage^t	1.72E−03
Purine Nucleosides Salvage II (Plant)^t	2.95E−03
Cytokinins degradation^t	3.43e−03
Purine nucleotide salvage^t	7.72e−03
l-methionine salvage^t	2.19E−02
l-methionine biosynthesis^t	3.06E−02
Purine nucleotide biosynthesis^t	4.04e−02

Letter(s) after the pathways and metabolites indicate the involved metabolites in the same pathway. Enrichment analysis was carried out using the Fisher Exact statistical test.