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. 2020 Dec 14;10:21917. doi: 10.1038/s41598-020-79071-x

Table 1.

Characteristics of included studies.

Study Year Country Time frame Sample size Age (median, year) Histology FIGO Stage Follow-up duration (median) Treatment strategy Cut-off value
Jonska-Gmyrek et al 2018 Poland 2003–2008 94 53 ADC IA–IVB 66 mons Mixed 1.6
Nuchpramool et al 2018 Thailand 2001–2016 460 47 Mixed IA2–IB1 57 mons Surgery ± AT 1.8
Ida et al 2018 Japan 2004–2015 79 52.4# Mixed NR 15 mons Mixed 2.8
Holub et al 2018 Spain 2009–2016 151 51 Mixed IA–IVB 44 mons Mixed 3.8
He et al 2018 China 2007–2009 229 44 Mixed I–IV 83 mons Mixed 1.6
Koulis et al 2017 Canada 1998–2012 257 50 Mixed IB–IVA 41 mons CCRT or RT 5
Cho et al.* 2016 Korea 1986–2012 2456 56 Mixed IA–IVA 65 mons CCRT or RT 2.5
Wang et al.* 2016 China 2009–2010 60 53 SCC II–III 58 mons CCRT 2
Onal et al.* 2016 Turkey 2006–2014 235 57 Mixed IB2–IVA 32 mons CCRT 3.03
Haraga et al.* 2016 Japan 2007–2013 36 61.5# Mixed IB1–IVA 30 mons RT 2.85
Chen et al.* 2016 China 2006–2009 407 44 NR IB1–IIA NR Surgery ± AT 2.42
Mizunuma et al.* 2015 Japan 2005–2013 56 65.1 SCC IB1–IV 14 mons# CCRT or RT 2.5
Zhang et al.* 2014 China 2005–2008 460 44 Mixed I–II 69 mons Surgery ± AT 2.213
Lee et al.* 2012 Korea 1996–2007 1061 50 Mixed IB1–IVA 53 mons Mixed 1.9

NR not reported,  ± AT with/without adjuvant therapy, CCRT cisplatin-based concurrent chemoradiotherapy, RT radiotherapy, ADC adenocarcinoma of cervix, SCC squamous carcinoma of cervix, FIGO International Federation of Gynecology and Obstetrics.

#Mean age of the sample.

#Mean follow up duration of the sample.

*Included in previous meta-analysis.