Table 3.
Mean cytokine concentration in healthy controls and atopic dermatitis.
| Cytokine | Concentration pg/μg protein (mean ± SD) | P-value | ||
|---|---|---|---|---|
| HC | AD NLS | AD LS | ||
| IL-1α | 57.2 ± 43.3 | 49.7 ± 54.9 | 4.9 ± 6.8 |
HC-NLS: 0.43 HC-LS: < 0.0001 NLS-LS: < 0.0001 |
| IL-1β | 43.9 ± 33.8 | 547 ± 926.4 | 331.7 ± 315.2 |
HC-NLS: < 0.0001 HC-LS: 0.0003 NLS-LS: 0.09 |
| IL-5 | 6.1 ± 4.5 | 7.6 ± 11.3 | 6.9 ± 8.0 |
HC-NLS 1.0 HC-LS 0.5 NLS-LS 0.68 |
| IL-18 | 210.3 ± 294.8 | 1814 ± 3226 | 20,383 ± 30,681 |
HC-NLS: 0.045 HC-LS: < 0.0001 NLS-LS: < 0.0001 |
| IFN-γ | 42.1 ± 21.9 | 57.2 ± 53.7 | 41.1 ± 34.7 |
HC-NLS 0.73 HC-LS 0.69 NLS-LS 0.17 |
| CCL17/TARC | 10.2 ± 16.5 | 283 ± 847.6 | 569.7 ± 603.8 |
HC-NLS: 0.0005 HC-LS: < 0.0001 NLS-LS: 0.008 |
| CCL22/MDC | 1756 ± 1212 | 6233 ± 10,298 | 8010 ± 6993 |
HC-NLS: 0.009 HC-LS: < 0.0001 NLS-LS: 0.15 |
| CCL27/CTACK | 25.6 ± 29.6 | 412.6 ± 850.4 | 1526 ± 1369 |
HC-NLS: 0.002 HC-LS: < 0.0001 NLS-LS: 0.0009 |
| CXCL8/IL-8 | 14.7 ± 34.0 | 1481 ± 4201 | 6984 ± 8099 |
HC-NLS: 0.0007 HC-LS: < 0.0001 NLS-LS: 0.002 |
| CXCL10/P-10 | 8.1 ± 7.0 | 148.2 ± 469.7 | 307.5 ± 350.3 |
HC-NLS: 0.006 HC-LS: < 0.0001 NLS-LS: 0.015 |
| TNF-α | 8.4 ± 7.0 | 21.6 ± 22.7 | 25.5 ± 31.4 |
HC-NLS: 0.0007 HC-LS: < 0.0001 NLS-LS: 0.021 |
| TSLP | 1.59 ± 1.4 | 15.5 ± 55.9 | 41.5 ± 62.6 |
HC-NLS: 0.0009 HC-LS: < 0.0001 NLS-LS: 0.0067 |
| VEGFA | 251.7 ± 201.2 | 609 ± 615.4 | 1265 ± 597.2 |
HC-NLS: 0.016 HC-LS: < 0.0001 NLS-LS: 0.0002 |
Bold letters indicate statistical significant p-values.
Mean concentration of each cytokine ± standard deviation (SD) within healthy control (HC) skin, atopic dermatitis (AD) non-lesional skin (NLS) and AD lesional skin (LS). Comparison between LS and NLS are made with Wilcoxon test. Comparison between HC and LS, and HC and NLS are made with Kruskal–Wallis and FDR Benjamini–Hochberg correction.