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Schematic of the human JAK2 protein. The three most common gain-of-function mutations are indicated. Ex12, exon 12; Ex13InDel, exon13 insertion/deletion; p.V617F, p.Val617Phe. FERM, amino acids 37–380; SH2, amino acids 401–482; Pseudokinase, amino acids 545–808; Kinase, amino acids 849–1124.
