Fig. 3.

a Phylogenetic tree showing homology of cochaperones containing TPR domains. The sequences corresponding to the TPR domains of human cochaperones were aligned with Clustal Omega. The accession sequences for each cochaperone are listed in Table S2. b, c The Genotype-Tissue Expression (GTEx) database (gtexportal.org) was used to compare mRNA expression data for each of the cochaperones across a range of human tissues. Brain = frontal cortex, heart = atrial appendage. The hatched polygons show the mean transcripts per million (TPM) of the mRNA encoding the indicated cochaperone in the tissue shown. Darker colors represent higher expression levels