Figure 1.

Ganglioside D3 is expressed in depigmenting skin of human and mouse origin. (A) Expression of GD3 and (B) a lack of melanocytes, as represented by an absence of TRP-1+ staining, were found in human depigmenting epidermis from perilesional patient skin. Whereas (C) limited GD3 expression and (D) abundant TRP-1 expression are shown in healthy control skin. (E) In depigmenting mouse skin, GD3 expressing cells were observed around hair follicles and in proximity to the epidermis. Representative staining of GD3 expressing cells is shown in red with nuclei in blue, around autofluorescent mouse hairs (Scale bar = 50μm).