Table 1.

Key features of current personal CGM systems

Feature	FreeStyle Libre 2	Dexcom G6	Medtronic Guardian Connect	Eversense
Indication, years of age	≥4	≥2	≥7	≥18
Sensor wear, days	14	10	7	90 (US), 180 (Europe)
Requires fingerstick test calibration	no	no	2 x/day	2x/day
Warm up period (hrs)	1	2	2	24 (upon insertion of the sensor)*
Requires confirmatory fingerstick test for insulin dosing	no	no	yes	no
Active alarms/alerts	yes	yes	yes	yes
Real-time remote monitoring (data sharing)	yes	yes	yes	yes
Connects with insulin pump	no	yes	yes	no
Accuracy: Overall’ MARD, %	9.3 [28]	9.0[29]	10.4[30]	9.0[31]
Chemical substances Interferences	Ascorbic Acid; Salicylic Acid [32]	Hydroxyurea; [29] repeated doses of APAP [33]	Acetaminophen; Ethanol/Wine; Albuterol; Lisinopril; Atenolol; Atorvastatin; Ascorbic Acid [34]	Tetracycline; Mannitol [35]
Interferences from Radiological Studies	Limited evidence of in-vitro exposure to X-Ray and RT, CT or MRI did not impact the data recorded by Libre Pro in 10 sensors [36]	No impact from X-Ray, CT or angiography among hospitalized patients (n=49); [37] there is some migration from MRI [38]	Medtronic recommends that users remove the sensor in the presence of X-ray, CT, MRI PET, Airport scanners [39]	Close contact with direct electromagnetic interference (EMI) may interfere with the smart transmitter’s ability to send data to the mobile device. [40]

^*The U.S. Food & Drug Administration cautions that readings from the first 12 hours of use should not form the basis of treatment decisions. MARD : Mean Absolute Relative Difference