Table 1.
Summary table of sarcomere and sarcomere-associated proteins with their proposed degradation mechanisms.
| Protein | Function | Proposed Degradation Mechanisms |
|---|---|---|
| Actin | Thin filament | TRIM32 [174] |
| α-Actinin | Actin cross-linking | Fbxl22 [186], TRIM32 [175] |
| Ankyrin | Cytoskeletal adaptor | Calpains [204,223] |
| Desmin | Cytoskeletal adaptor | Calpains [153,224], TRIM32 [175,176], Atrogin-1 [187], Cullin-5 [184,185] |
| Dystrophin | Cytoskeletal adaptor | Calpains [149,225] |
| FHL2 | Sarcomere/nucleus crosstalk | MuRF-3 [168] |
| Filamin A and C | Actin cross-linking | Calpains [226,227], Cullin-5 [184,185], Fbxl22 [186], MuRF-3 [168], CASA [196] |
| MYBPC | Thick filament regulation | Calpains [228,229], MuRF-1 [166] |
| β-MHC | Thick filament | MuRF1–3 [164,166], CHIP [178] |
| MLC-2 | Thick filament regulation | MuRF1–2 [164] |
| Myotilin | Z-disc integrity | MuRF1–2 [164], TRIM32 [175] |
| Nebulin/Nebulette | Thin filament stability | Calpains [230,231], MuRF1–2 [164] |
| NRAP | Thin filament stability | MuRF1–2 [164] |
| Telethonin/T-cap | Titin stability | Mdm2 [182], MuRF1–2 [164] |
| Titin | Strain-sensing, scaffold | Calpains [149,232], MuRF1–2 [164] |
| Tropomodulin/T-mod | Thin filament stability | Calpains [233] |
| Troponin C | Thin filament regulation | MuRF-1 [165] |
| Troponin I | Thin filament regulation | Calpains [208,211,234,235], MuRF1–2 [164,165], TRIM32 [175], c-Cbl [188] |
| Troponin T | Thin filament regulation | Calpains [208,234,235], MuRF1–2 [164], TRIM32 [175] |
| Tropomyosin | Thin filament regulation | Calpains [149,230], TRIM32 [175] |