Table.

Effect of established and candidate anxiolytics on potentiated startle

Drugs	Doses	Acute/chronic	Baseline startle	FPS	APS	References
Alprazolam	.5 mg, 1 mg	Acute	↓5	−	↓7	Grillon et al., 2006b
Alprazolam	1 mg	Acute	↓	−	↓	Grillon et al., 2015
Citalopram	20 mg/day	14 days	−	−	↓	Grillon et al., 2009a
GSK5616791	50 mg, 400 mg	Acute	−	↑6	−	Grillon et al., 2015
LY3547402	20 mg, 200 mg	Acute	−	−	↓	Grillon et al., 2003
Oxytocin	24 IU$	Acute	−	↑	−	Grillon et al., 2013
Prazosin3	2 mg	Acute	−	−	−	Kaye et al., 2019
SRX2464	300 mg	4–7 days	−	−	↓	Lago et al., 2020

¹CRF1 antagonist (Verucerfont)

²Group II mGlu2/3 agonist

³norepinephrine alpha-1 (NE-α1) antagonist

⁴V1a receptor antagonist

⁵1 mg only

⁶400 mg only

⁷nasal spray