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. Author manuscript; available in PMC: 2020 Dec 15.
Published in final edited form as: J Bone Miner Res. 2020 Sep 19;35(12):2432–2443. doi: 10.1002/jbmr.4142

Figure 4. Mice treated with LDH inhibitor oxamate have increased bone mineral density without any signs of toxicity.

Figure 4.

A) Eight-week-old male C57BL/6J mice were treated with 100 mg/kg OXA or PBS twice per week for 2 mo and tissues were collected for various analyses. OXA toxicity was assessed and compared to PBS-treated controls: (B) Body weight; (C) serum ALT (liver toxicity); (D) serum creatinine (kidney marker). Whole body composition was measured via DEXA: (E) % body fat; (F) Lean mass; G) Bone mineral density (BMD). Data are presented as boxplots with actual data points, median, and range. P value was determined by unpaired t-test and shown in data sets with p < 0.05.