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. Author manuscript; available in PMC: 2020 Dec 15.
Published in final edited form as: J Bone Miner Res. 2020 Sep 19;35(12):2432–2443. doi: 10.1002/jbmr.4142

Figure 6. LDH inhibition stimulates osteoblast bone forming activity without affecting bone resorption in mice.

Figure 6.

(A) Analysis of osteoblast bone forming function using dynamic bone histomorphometry and calcein double labeling. (B – D) OXA treatment of mice led to a significant increase in mineral apposition rate (MAR) and bone formation rate (BFR) in the endocortical compartment of femoral bone. (E) Analysis of osteoclast-specific TRAP staining and Visiopharm technology-based automated histomorphometry. (F) Bone resorption was not significantly affected in OXA-treated mice when compared to PBS-treated controls. Data are presented as boxplots with actual data points, median, and range. P value was determined by unpaired t-test and shown in data sets with p < 0.05.